Extended Release Dosage Forms

 

Chapter 9: Solid Oral EXTENDED RELEASE Dosage Forms
ADVANTAGE	Criteria
Less fluctuation in blood levels	Not slow or fast absorption/excretion
Frequency reduction in dosing	Uniformly absorb GI tract
Enhanced convenience and compliance	Good margin of SAFETY
Reduction of adverse effect	FOR CHRONIC CONDITIONS
Reduction in overall cost
TERMS
Modified Release	Features not offered by conventional forms  Based on time course location
Extended release	Reduction in dosing frequency
Delayed release	Could be enteric coated (gastric pH) Release drug at a time other than promptly after admin
Repeat Action	Contain two single dose 1.       Immediate release 2.       Delayed release
Targeted Release	Directingor isolating drug in body region, tissue or site for absorption or for drug action
TECHNOLOGY
1.       Multitablet
2.       Microencapsulation	S,l,gas, enclosed in microscopic particle
3.       Osmotic PUMP	OROS system Termed GITS GI therapeutic system Glucotrol XL, Procardia XL   COER (controlled onset ext release)  Covera-HS tabs
Repeat action tabs	Repetab